PyMe is a Python interface to GPGME library. PyMe's development model is GPGME + Python + SWIG (just like m2crypto is an OpenSSL + Python + SWIG) combination which means that most of the functions and types are converted from C into Python automatically by SWIG. In short, to be able to use PyMe you need to be familiar with GPGME. WWW: http://pyme.sourceforge.net/